Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary
cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer …

Breast cancer is the most commonly occurring cancer in women of Western countries and is
the leading cause of cancer-related mortality. The breast tumor microenvironment contains …

It has been well documented that the tumor microenvironment (TME) plays a key role in the
promotion of drug resistance, the support of tumor progression, invasiveness, metastasis …

Chemotherapy is the main treatment for cancer therapy. However, its anti-tumor efficiency is
always impaired by the poor bioavailability and low tumor accumulation of …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …

Cancer cells are disordered by nature and thus featured by higher internal redox level than
healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain …

Tumor angiogenesis is one of the most important processes of cancer deterioration via
nurturing an immunosuppressive tumor environment (TME). Targeting tumor angiogenesis …

A large body of experimental research reveals that tumor-associated macrophages (TAMs)
are the major immunosuppressor cells in the breast tumor microenvironment (TME). The …

Cancer stem cells (CSC) are supported by the tumor microenvironment, and non-CSCs can
regain CSC phenotypes in certain niches, leading to limited clinical benefits of CSC-targeted …

Aberrant expression of epidermal growth factor receptor (EGFR) plays a critical role in the
pathogenesis of various tumors, potentially representing a target for therapeutic intervention …