RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …

Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

An unheard mobilization of resources to find SARS-CoV-2 vaccines and therapies has been
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …

Abstract mRNA vaccines have become a promising platform for cancer immunotherapy.
During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …