Recent progress and trends in X-ray-induced photodynamic therapy with low radiation doses

L He, X Yu, W Li - ACS nano, 2022 - ACS Publications
The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires
innovative solutions for its congenitally deficient shadow penetration of the visible-light …

Metallic nanoparticles as drug delivery system for the treatment of cancer

N Desai, M Momin, T Khan, S Gharat… - Expert opinion on …, 2021 - Taylor & Francis
Introduction The targeted delivery of anticancer agents to tumor is a major challenge
because most of the drugs show off-target effect resulting in nonspecific cell death …

Nanomedicine for brain cancer

S Quader, K Kataoka, H Cabral - Advanced Drug Delivery Reviews, 2022 - Elsevier
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)

C Verry, S Dufort, J Villa, M Gavard, C Iriart… - Radiotherapy and …, 2021 - Elsevier
Background and purpose Brain metastasis impacts greatly on patients' quality of life and
survival. The phase I NANO-RAD trial assessed the safety and maximum tolerated dose of …

Nano-delivery to the lung-by inhalation or other routes and why nano when micro is largely sufficient?

V Forest, J Pourchez - Advanced Drug Delivery Reviews, 2022 - Elsevier
Respiratory diseases gather a wide range of disorders which are generally difficult to treat,
partly due to a poor delivery of drugs to the lung with adequate dose and minimum side …

Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors

S Reddy, K Tatiparti, S Sau, AK Iyer - Drug Discovery Today, 2021 - Elsevier
Gliomas constitute about 80% of brain tumors and have a meager two-year survival rate.
The treatment options available are very few because of poor prognosis and a lack of …

Nanomedicines and nanomaterials for cancer therapy: Progress, challenge and perspectives

Z **g, Q Du, X Zhang, Y Zhang - Chemical Engineering Journal, 2022 - Elsevier
The field of nanomedicines and nanomaterials has been rapidly develo** with several
considerable breakthroughs in the treatment of cancer. However, some challenges may …

Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

J Schuemann, AF Bagley, R Berbeco… - Physics in Medicine …, 2020 - iopscience.iop.org
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to …

Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective

C Verry, S Dufort, B Lemasson, S Grand, J Pietras… - Science …, 2020 - science.org
The use of radiosensitizing nanoparticles with both imaging and therapeutic properties on
the same nano-object is regarded as a major and promising approach to improve the …

EPR-mediated tumor targeting using ultrasmall-hybrid nanoparticles: From animal to human with theranostic AGuIX nanoparticles

G Bort, F Lux, S Dufort, Y Crémillieux, C Verry… - …, 2020 - pmc.ncbi.nlm.nih.gov
Interest of tumor targeting through EPR effect is still controversial due to intrinsic low
targeting efficacy and rare translation to human cancers. Moreover, due to different reasons …