Cancers make their own luck: theories of cancer origins
A Jassim, EP Rahrmann, BD Simons… - Nature reviews …, 2023 - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
Deconstructing sonic hedgehog medulloblastoma: molecular subtypes, drivers, and beyond
Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnosed
during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH …
during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH …
CysDB: a human cysteine database based on experimental quantitative chemoproteomics
Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential"
druggability" for thousands of cysteine residues. Consequently, these studies are facilitating …
druggability" for thousands of cysteine residues. Consequently, these studies are facilitating …
[HTML][HTML] Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …
differences lies in the sex chromosomes. Although the functions of the X chromosome …
Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
Medulloblastoma (MB) is the most common malignant childhood brain tumour,, yet the origin
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …
Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model
Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …
SJPedPanel: a pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection
P Kolekar, V Balagopal, L Dong, Y Liu… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: The purpose of the study was to design a pan-cancer gene panel for childhood
malignancies and validate it using clinically characterized patient samples. Experimental …
malignancies and validate it using clinically characterized patient samples. Experimental …
Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation
EJ Radford, HK Tan, MHL Andersson… - Nature …, 2023 - nature.com
Loss-of-function of DDX3X is a leading cause of neurodevelopmental disorders (NDD) in
females. DDX3X is also a somatically mutated cancer driver gene proposed to have tumour …
females. DDX3X is also a somatically mutated cancer driver gene proposed to have tumour …
Biological functions of DEAD/DEAH-box RNA helicases in health and disease
O Andrisani, Q Liu, P Kehn, WW Leitner, K Moon… - Nature …, 2022 - nature.com
On 15–16 November 2021, the National Institute of Allergy and Infectious Diseases (NIAID),
the National Cancer Institute (NCI) and the National Heart, Lung, and Blood Institute (NHLBI) …
the National Cancer Institute (NCI) and the National Heart, Lung, and Blood Institute (NHLBI) …
DDX3X and DDX3Y are redundant in protein synthesis
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X-and
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …