Large-scale neural recordings call for new insights to link brain and behavior

AE Urai, B Doiron, AM Leifer, AK Churchland - Nature neuroscience, 2022 - nature.com
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

Computational neuroethology: a call to action

SR Datta, DJ Anderson, K Branson, P Perona, A Leifer - Neuron, 2019 - cell.com
The brain is worthy of study because it is in charge of behavior. A flurry of recent technical
advances in measuring and quantifying naturalistic behaviors provide an important …

Natural behavior is the language of the brain

CT Miller, D Gire, K Hoke, AC Huk, D Kelley… - Current Biology, 2022 - cell.com
The breadth and complexity of natural behaviors inspires awe. Understanding how our
perceptions, actions, and internal thoughts arise from evolved circuits in the brain has …

Are we ready for real-world neuroscience?

PJ Matusz, S Dikker, AG Huth… - Journal of cognitive …, 2019 - direct.mit.edu
Real-world environments are typically dynamic, complex, and multisensory in nature and
require the support of top–down attention and memory mechanisms for us to be able to drive …

Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice

D Scheggia, F La Greca, F Maltese… - Nature …, 2022 - nature.com
Decisions that favor one's own interest versus the interest of another individual depend on
context and the relationships between individuals. The neurobiology underlying selfish …

Movement-related signals in sensory areas: roles in natural behavior

PRL Parker, MA Brown, MC Smear, CM Niell - Trends in neurosciences, 2020 - cell.com
Recent studies have demonstrated prominent and widespread movement-related signals in
the brain of head-fixed mice, even in primary sensory areas. However, it is still unknown …

Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

SS Bolkan, IR Stone, L Pinto, ZC Ashwood… - Nature …, 2022 - nature.com
A classic view of the striatum holds that activity in direct and indirect pathways oppositely
modulates motor output. Whether this involves direct control of movement, or reflects a …

Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

AL Juavinett, G Bekheet, AK Churchland - Elife, 2019 - elifesciences.org
The advent of high-yield electrophysiology using Neuropixels probes is now enabling
researchers to simultaneously record hundreds of neurons with remarkably high signal to …

Ecological validity of social interaction tests in rats and mice

K Kondrakiewicz, M Kostecki… - Genes, Brain and …, 2019 - Wiley Online Library
Different rat and mouse models are used in studies of social interactions. Simple behavioral
measures, which are commonly used in the laboratory, allow to perform relatively short …

A head-mounted camera system integrates detailed behavioral monitoring with multichannel electrophysiology in freely moving mice

AF Meyer, J Poort, J O'Keefe, M Sahani, JF Linden - Neuron, 2018 - cell.com
Breakthroughs in understanding the neural basis of natural behavior require neural
recording and intervention to be paired with high-fidelity multimodal behavioral monitoring …