Isotachophoresis: theory and microfluidic applications

A Ramachandran, JG Santiago - Chemical Reviews, 2022‏ - ACS Publications
Isotachophoresis (ITP) is a versatile electrophoretic technique that can be used for sample
preconcentration, separation, purification, and mixing, and to control and accelerate …

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2012–2014)

MC Breadmore, RM Tubaon, AI Shallan… - …, 2015‏ - Wiley Online Library
One of the most cited limitations of capillary (and microchip) electrophoresis is the poor
sensitivity. This review continues to update this series of biannual reviews, first published in …

Two orders of magnitude improvement in detection limit of lateral flow assays using isotachophoresis

BY Moghadam, KT Connelly, JD Posner - Analytical chemistry, 2015‏ - ACS Publications
Lateral flow immunoassays (LFA) are one of the most prevalent point-of-care (POC)
diagnostics due to their simplicity, low cost, and robust operation. A common criticism of LFA …

1000-fold sample focusing on paper-based microfluidic devices

T Rosenfeld, M Bercovici - Lab on a Chip, 2014‏ - pubs.rsc.org
We present an experimental and analytical study of a novel paper-based analytical device
(μPAD) for isotachophoretic sample focusing. Guided by a simple heat transfer model, we …

Oxidized porous silicon nanostructures enabling electrokinetic transport for enhanced DNA detection

R Vilensky, M Bercovici, E Segal - Advanced Functional …, 2015‏ - Wiley Online Library
Nanostructured porous silicon (PSi) is a promising material for the label‐free detection of
biomolecules, but it currently suffers from limited applicability due to poor sensitivity, typically …

Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis

T Rosenfeld, M Bercovici - Lab on a Chip, 2018‏ - pubs.rsc.org
We present a novel microfluidic paper-based analytical device (μPAD) which utilizes the
native high electroosmotic flow (EOF) in nitrocellulose to achieve stationary …

On chip protein pre-concentration for enhancing the sensitivity of porous silicon biosensors

S Arshavsky-Graham, N Massad-Ivanir, F Paratore… - ACS …, 2017‏ - ACS Publications
Porous silicon (PSi) nanomaterials have been widely studied as label-free optical
biosensors for protein detection. However, these biosensors' performance, specifically in …

Weight shift keying (wsk) with practical mechanical receivers for molecular communications in internet of everything

D Aktas, OB Akan - IEEE Journal on Selected Areas in …, 2022‏ - ieeexplore.ieee.org
Molecular communication (MC) is one of the emerging technologies enabling nanonetworks
and the Internet of Everything (IoE). The practical implementation of the intra-body MC …

Increasing hybridization rate and sensitivity of DNA microarrays using isotachophoresis

CM Han, E Katilius, JG Santiago - Lab on a Chip, 2014‏ - pubs.rsc.org
We present an on-chip electrokinetic method to increase the reaction kinetics and sensitivity
of DNA microarray hybridization. We use isotachophoresis (ITP) to preconcentrate target …

Isotachophoresis applied to biomolecular reactions

C Eid, JG Santiago - Lab on a Chip, 2018‏ - pubs.rsc.org
This review discusses research developments and applications of isotachophoresis (ITP) to
the initiation, control, and acceleration of chemical reactions, emphasizing reactions …