The basic features of DNA were elucidated during the half-century following the discovery of
the double helix. But it is only during the past decade that researchers have been able to …

Large differences between the DPP responses of ss-and dsDNAs (Figure 4B) suggest that
the double-helical structure of the dsDNA is not significantly disturbed at the DME surface …

Etoposide is a broadly employed chemotherapeutic and eukaryotic topoisomerase II poison
that stabilizes cleaved DNA intermediates to promote DNA breakage and cytotoxicity. How …

Abstract Knowledge of the elastic properties of DNA is required to understand the structural
dynamics of cellular processes such as replication and transcription. Measurements of force …

I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Using a modified atomic force microscope (AFM), individual double-stranded (ds) DNA
molecules attached to an AFM tip and a gold surface were overstretched, and the …

Cellular DNA is continuously engaged in a molecular dance with many accessory proteins.
These proteins are responsible for orchestrating the storage, maintenance, and transfer of …

The elastic properties of DNA are essential for its biological function. They control its
bending and twisting as well as the induction of structural modifications in the molecule …

In cells, DNA is constantly twisted, bent and stretched by numerous proteins mediating
genome transactions. Understanding these essential biological processes requires in-depth …

Methods for manipulating single molecules are yielding new information about both the
forces that hold biomolecules together and the mechanics of molecular motors. We describe …