Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in develo** an effective therapy …

Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that
primarily affects upper and lower motor neurons, but also frontotemporal and other regions …

Background Riluzole is the only drug to prolong survival for amyotrophic lateral sclerosis
(ALS) and, at a dose of 100 mg, was associated with a 35% reduction in mortality in a …

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …

Objective To elucidate the relationship between disease stage in amyotrophic lateral
sclerosis (ALS), as measured with the King's Clinical Staging System, and cognitive and …

Recently, an astrocytic aquaporin 4-dependent drainage system, that is, the glymphatic
system, has been identified in the live murine and human brain. Growing evidence suggests …

Objective To assess the association of the degree of severity of motor impairment to that of
cognitive impairment in a large cohort of patients with amyotrophic lateral sclerosis (ALS) …