Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

Emerging applications of nanotechnology in healthcare and medicine

S Malik, K Muhammad, Y Waheed - Molecules, 2023 - mdpi.com
Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …

Polymer‐based mRNA delivery strategies for advanced therapies

W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

Advances in mRNA therapeutics for cancer immunotherapy: from modification to delivery

G Han, D Noh, H Lee, S Lee, S Kim, HY Yoon… - Advanced Drug Delivery …, 2023 - Elsevier
RNA vaccines have demonstrated their ability to solve the issues posed by the COVID-19
pandemic. This success has led to the renaissance of research into mRNA and their …

[HTML][HTML] Viral and non-viral systems to deliver gene therapeutics to clinical targets

M Taghdiri, C Mussolino - International Journal of Molecular Sciences, 2024 - mdpi.com
Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled …

Biopolymeric nanoparticles–multifunctional materials of the future

AA Vodyashkin, P Kezimana, AA Vetcher… - Polymers, 2022 - mdpi.com
Nanotechnology plays an important role in biological research, especially in the
development of delivery systems with lower toxicity and greater efficiency. These include not …

[HTML][HTML] Unlocking the mitochondria for nanomedicine-based treatments: overcoming biological barriers, improving designs, and selecting verification techniques

C Pegoraro, I Domingo-Ortí, I Conejos-Sánchez… - Advanced Drug Delivery …, 2024 - Elsevier
Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …

Recent advances in lipid nanoparticles for delivery of mRNA

L Yang, L Gong, P Wang, X Zhao, F Zhao, Z Zhang… - Pharmaceutics, 2022 - mdpi.com
Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic
information and direct protein synthesis, is transcribed from a strand of DNA as a template …

Dynamic carriers for therapeutic RNA delivery

S Berger, U Lächelt, E Wagner - Proceedings of the …, 2024 - National Acad Sciences
Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA
during delivery to the target tissue and across cellular membrane barriers and then …

Polyplex designs for improving the stability and safety of RNA therapeutics

S Uchida, CYJ Lau, M Oba, K Miyata - Advanced Drug Delivery Reviews, 2023 - Elsevier
Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …