Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Emerging applications of nanotechnology in healthcare and medicine
Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …
Polymer‐based mRNA delivery strategies for advanced therapies
W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …
Advances in mRNA therapeutics for cancer immunotherapy: from modification to delivery
RNA vaccines have demonstrated their ability to solve the issues posed by the COVID-19
pandemic. This success has led to the renaissance of research into mRNA and their …
pandemic. This success has led to the renaissance of research into mRNA and their …
[HTML][HTML] Viral and non-viral systems to deliver gene therapeutics to clinical targets
M Taghdiri, C Mussolino - International Journal of Molecular Sciences, 2024 - mdpi.com
Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled …
protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled …
Biopolymeric nanoparticles–multifunctional materials of the future
Nanotechnology plays an important role in biological research, especially in the
development of delivery systems with lower toxicity and greater efficiency. These include not …
development of delivery systems with lower toxicity and greater efficiency. These include not …
[HTML][HTML] Unlocking the mitochondria for nanomedicine-based treatments: overcoming biological barriers, improving designs, and selecting verification techniques
C Pegoraro, I Domingo-Ortí, I Conejos-Sánchez… - Advanced Drug Delivery …, 2024 - Elsevier
Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …
Recent advances in lipid nanoparticles for delivery of mRNA
L Yang, L Gong, P Wang, X Zhao, F Zhao, Z Zhang… - Pharmaceutics, 2022 - mdpi.com
Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic
information and direct protein synthesis, is transcribed from a strand of DNA as a template …
information and direct protein synthesis, is transcribed from a strand of DNA as a template …
Dynamic carriers for therapeutic RNA delivery
Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA
during delivery to the target tissue and across cellular membrane barriers and then …
during delivery to the target tissue and across cellular membrane barriers and then …
Polyplex designs for improving the stability and safety of RNA therapeutics
Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …