Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Large-scale cell death is commonly observed during organismal development and in human
pathologies,,,–. These cell death events extend over great distances to eliminate large …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

The cytotoxic effect of anti-cancer drugs relies on their ability to induce programmed cell
death known as apoptosis. Evading apoptosis is a common characteristic of cancer cells …

The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Cell death events continuously challenge epithelial barrier function yet are crucial to
eliminate old or critically damaged cells. How such apoptotic events are spatio-temporally …

Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …