Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy

L Sivapalan, JC Murray… - Journal for …, 2023 - pmc.ncbi.nlm.nih.gov
Circulating cell-free tumor DNA (ctDNA) can serve as a real-time biomarker of tumor burden
and provide unique insights into the evolving molecular landscape of cancers under the …

Integrating circulating-free DNA (cfDNA) analysis into clinical practice: opportunities and challenges

M Garcia-Pardo, M Makarem, JJN Li, D Kelly… - British Journal of …, 2022 - nature.com
In the current era of precision medicine, the identification of genomic alterations has
revolutionised the management of patients with solid tumours. Recent advances in the …

White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

A Leal, NCT van Grieken, DN Palsgrove… - Nature …, 2020 - nature.com
Liquid biopsies are providing new opportunities for detection of residual disease in cell-free
DNA (cfDNA) after surgery but may be confounded through identification of alterations …

Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)

B Ricciuti, G Jones, M Severgnini… - Journal for …, 2021 - pmc.ncbi.nlm.nih.gov
Background Currently available biomarkers are imperfect in their ability to predict responses
to the multiple first-line treatment options available for patients with advanced non-small cell …

Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer

J Yang, Y Gong, VK Lam, Y Shi, Y Guan, Y Zhang… - Cell death & …, 2020 - nature.com
Identifying locoregional gastric cancer patients who are at high risk for relapse after
resection could facilitate early intervention. By detecting molecular residual disease (MRD) …

Liquid biopsy in the clinical management of hepatocellular carcinoma

J von Felden, T Garcia-Lezana, K Schulze, B Losic… - Gut, 2020 - gut.bmj.com
With increasing knowledge on molecular tumour information, precision oncology has
revolutionised the medical field over the past years. Liquid biopsy entails the analysis of …

[HTML][HTML] The liquid biopsy for lung cancer: state of the art, limitations and future developments

D Di Capua, D Bracken-Clarke, K Ronan, AM Baird… - Cancers, 2021 - mdpi.com
Simple Summary During the development and progression of lung tumors, processes such
as necrosis and vascular invasion shed tumor cells or cellular components into various fluid …

Current and future applications of liquid biopsy in nonsmall cell lung cancer from early to advanced stages

N Guibert, A Pradines, G Favre… - European Respiratory …, 2020 - publications.ersnet.org
Liquid biopsy refers to the analysis of any tumour-derived material circulating in the blood or
any other body fluid. This concept is particularly relevant in lung cancer as the tumour is …

[HTML][HTML] Biomarkers and lung cancer early detection: state of the art

E Dama, T Colangelo, E Fina, M Cremonesi… - Cancers, 2021 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer death worldwide. Detecting
lung malignancies promptly is essential for any anticancer treatment to reduce mortality and …

Genetics of hepatocellular carcinoma: from tumor to circulating DNA

C Campani, J Zucman-Rossi, JC Nault - Cancers, 2023 - mdpi.com
Simple Summary In recent years, the genetic landscape of hepatocellular carcinoma (HCC)
has been explored, identifying TERT promoter, CTNNB1, and TP53 as the most frequent …