The AP-1 transcriptional complex: Local switch or remote command?
F Bejjani, E Evanno, K Zibara, M Piechaczyk… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
Transcriptional regulation by calcium, calcineurin, and NFAT
The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …
Rewiring cancer drivers to activate apoptosis
Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have
been identified for many human cancers,,–. Independent studies have identified cell death …
been identified for many human cancers,,–. Independent studies have identified cell death …
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells
During persistent antigen stimulation, CD8+ T cells show a gradual decrease in effector
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into
osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles …
osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles …
Origins of specificity in protein-DNA recognition
Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …
processes. In this review, we provide a revised view of protein-DNA interactions that …
NFAT proteins: key regulators of T-cell development and function
F Macian - Nature Reviews Immunology, 2005 - nature.com
Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a
decade ago, the NFAT family of transcription factors has grown to include five members. It …
decade ago, the NFAT family of transcription factors has grown to include five members. It …
Intrinsic disorder and protein function
The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
The molecular understanding of osteoclast differentiation
M Asagiri, H Takayanagi - Bone, 2007 - Elsevier
Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone
matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family …
matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family …
Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks
Basic leucine zipper transcription factor ATF-like (BATF), BATF2 and BATF3 belong to the
activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular …
activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular …