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Echinocandins–structure, mechanism of action and use in antifungal therapy
With increasing number of immunocompromised patients as well as drug resistance in fungi,
the risk of fatal fungal infections in humans increases as well. The action of echinocandins is …
the risk of fatal fungal infections in humans increases as well. The action of echinocandins is …
Oral candidiasis: A disease of opportunity
Oral candidiasis, commonly referred to as “thrush,” is an opportunistic fungal infection that
commonly affects the oral mucosa. The main causative agent, Candida albicans, is a highly …
commonly affects the oral mucosa. The main causative agent, Candida albicans, is a highly …
Invasive candidiasis
Invasive candidiasis is an important health-care-associated fungal infection that can be
caused by several Candida spp.; the most common species is Candida albicans, but the …
caused by several Candida spp.; the most common species is Candida albicans, but the …
The global problem of antifungal resistance: prevalence, mechanisms, and management
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …
outcome. Only a few classes of antifungal drugs are available, so the emergence of …
Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …
along with significant agricultural crop loss caused by various fungal species, has resulted in …
Antifungal resistance: current trends and future strategies to combat
Antifungal resistance represents a major clinical challenge to clinicians responsible for
treating invasive fungal infections due to the limited arsenal of systemically available …
treating invasive fungal infections due to the limited arsenal of systemically available …
Invasive candidiasis
Despite advances in antifungal therapy, the mortality associated with invasive candidiasis
remains as high as 40%. This review summarizes recent trends and current strategies …
remains as high as 40%. This review summarizes recent trends and current strategies …
Molecular evolution of antifungal drug resistance
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
Emerging threats in antifungal-resistant fungal pathogens
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …
antifungal resistance. Resistance has been described for virtually all antifungal agents in …
Fosmanogepix: a review of the first-in-class broad spectrum agent for the treatment of invasive fungal infections
Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …