Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus
Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There …

Background The two available drugs for treatment of T. cruzi infection, nifurtimox and
benznidazole (BZ), have potential toxic side effects and variable efficacy, contributing to their …

Artemisia species are one of the many traditional medicinal plants of Ethiopia used for the
treatment of infectious and non-infectious health problems. In the present study, eight …

Essential oils from three Ethiopian medicinal plants; Hagenia abyssinica (Rosaceae),
Leonotis ocymifolia (Lamiaceae), and Moringa stenopetala (Moringaceae) were …

Neglected diseases caused by kinetoplastid parasites are a health burden in tropical and
subtropical countries. The need to create safe and effective medicines to improve treatment …

Objectives The aim was to determine the chemical composition of the essential oil of
Kadsura longipedunculata and the biological activity of the oil and its major components …

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key
enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on …

Leishmaniasis is an infection provoked by protozoans belonging to the genus Leishmania.
Among the many species and subsepecies of such protozoa, Leishmania donovani chagasi …

An α-carbonic anhydrase (CA, EC 4.2. 1.1) has been identified, cloned, and characterized
from the unicellular protozoan Trypanosoma cruzi, the causative agent of Chagas disease …