Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Recent applications of the multicomponent synthesis for bioactive pyrazole derivatives

D Becerra, R Abonia, JC Castillo - Molecules, 2022 - mdpi.com
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …

Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy

N Upadhyay, K Tilekar, F Loiodice, NY Anisimova… - Bioorganic …, 2021 - Elsevier
In search for new and safer anti-cancer agents, a structurally guided pharmacophore
hybridization strategy of two privileged scaffolds, namely diaryl pyrazolines and …

Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile

SK Ramadan, AK El-Ziaty… - Synthetic Communications, 2021 - Taylor & Francis
A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …

Synthesis and Application of Novel Magnetic Glycoluril Tetrakis(Methylene Phosphorous Acid) as a Nano Biological Catalyst for the Preparation of Nicotinonitriles via …

B Danishyar, H Sepehrmansourie, M Zarei… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we synthesized biological magnetic glycoluril tetrakis (methylene phosphorous acid)
as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@ GTMPA was …

Design, synthesis, anticancer evaluation and molecular docking study of novel 2, 4-dichlorophenoxymethyl-based derivatives linked to nitrogenous heterocyclic ring …

AA El-Sayed, ES Nossier, AA Almehizia… - Journal of Molecular …, 2022 - Elsevier
Abstract A novel series of 2, 4-dichlorophenoxymethyl-based derivatives 4-18 bearing
various nitrogenous heterocyclic systems have been designed and synthesized through …

Synthesis, characterization, and anticancer effect of novel Pyrazolopyranopyrimidines

AMA Hassan, ES Essam, L Ziko, MH Helal… - Journal of Molecular …, 2024 - Elsevier
Two novel β-enaminonitrile derivatives 5a, b bearing pyrano [2, 3-c] pyrazole moiety were
synthesized using Multi Component Reaction (MCR) technique by reacting the ethyl …

Synthesis and anti-rotavirus activity of some nitrogen heterocycles integrated with pyrazole scaffold

EAE El-Helw, MM Gado, AK El-Ziaty - Journal of the Iranian Chemical …, 2020 - Springer
Herein, the building block synthon 2-cyano-3-(1, 3-diphenyl-1 H-pyrazol-4-yl) acryloyl
chloride 4 was synthesized and utilized for construction of a wide variety of nitrogen …

Pyridine‐2(1H)‐thiones: Versatile precursors for one‐pot synthesis of new nicotinonitrile‐thiazole hybrids

SMH Sanad, AEM Mekky, AY Said… - Journal of …, 2021 - Wiley Online Library
In the current study, we report a facile procedure for the preparation of a new series of
nicotinonitrile‐thiazoles, in excellent isolated yields. For this purpose, pyridine‐2 (1 H) …

Insights into synthesis, reactivity, and biological activity of N-isoindoline-1, 3-diones heterocycles: a systematic literature review

Z Ou-Ichen, A Boussetta, K Ouchetto, A Hafid… - Journal of the Iranian …, 2024 - Springer
This review paper provides a comprehensive overview of recent advancements in the
synthesis, reactivity, and applications of N-isoindoline-1, 3-dione heterocycles. These …