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Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
Recent applications of the multicomponent synthesis for bioactive pyrazole derivatives
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy
In search for new and safer anti-cancer agents, a structurally guided pharmacophore
hybridization strategy of two privileged scaffolds, namely diaryl pyrazolines and …
hybridization strategy of two privileged scaffolds, namely diaryl pyrazolines and …
Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile
SK Ramadan, AK El-Ziaty… - Synthetic Communications, 2021 - Taylor & Francis
A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …
Synthesis and Application of Novel Magnetic Glycoluril Tetrakis(Methylene Phosphorous Acid) as a Nano Biological Catalyst for the Preparation of Nicotinonitriles via …
B Danishyar, H Sepehrmansourie, M Zarei… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we synthesized biological magnetic glycoluril tetrakis (methylene phosphorous acid)
as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@ GTMPA was …
as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@ GTMPA was …
Design, synthesis, anticancer evaluation and molecular docking study of novel 2, 4-dichlorophenoxymethyl-based derivatives linked to nitrogenous heterocyclic ring …
Abstract A novel series of 2, 4-dichlorophenoxymethyl-based derivatives 4-18 bearing
various nitrogenous heterocyclic systems have been designed and synthesized through …
various nitrogenous heterocyclic systems have been designed and synthesized through …
Synthesis, characterization, and anticancer effect of novel Pyrazolopyranopyrimidines
AMA Hassan, ES Essam, L Ziko, MH Helal… - Journal of Molecular …, 2024 - Elsevier
Two novel β-enaminonitrile derivatives 5a, b bearing pyrano [2, 3-c] pyrazole moiety were
synthesized using Multi Component Reaction (MCR) technique by reacting the ethyl …
synthesized using Multi Component Reaction (MCR) technique by reacting the ethyl …
Synthesis and anti-rotavirus activity of some nitrogen heterocycles integrated with pyrazole scaffold
Herein, the building block synthon 2-cyano-3-(1, 3-diphenyl-1 H-pyrazol-4-yl) acryloyl
chloride 4 was synthesized and utilized for construction of a wide variety of nitrogen …
chloride 4 was synthesized and utilized for construction of a wide variety of nitrogen …
Pyridine‐2(1H)‐thiones: Versatile precursors for one‐pot synthesis of new nicotinonitrile‐thiazole hybrids
In the current study, we report a facile procedure for the preparation of a new series of
nicotinonitrile‐thiazoles, in excellent isolated yields. For this purpose, pyridine‐2 (1 H) …
nicotinonitrile‐thiazoles, in excellent isolated yields. For this purpose, pyridine‐2 (1 H) …
Insights into synthesis, reactivity, and biological activity of N-isoindoline-1, 3-diones heterocycles: a systematic literature review
This review paper provides a comprehensive overview of recent advancements in the
synthesis, reactivity, and applications of N-isoindoline-1, 3-dione heterocycles. These …
synthesis, reactivity, and applications of N-isoindoline-1, 3-dione heterocycles. These …