[HTML][HTML] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication
BA Chau, V Chen, AW Cochrane, LJ Parent… - Cell Reports, 2023 - cell.com
The leap of retroviruses and coronaviruses from animal hosts to humans has led to two
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …
SARS‐CoV‐2 nucleocapsid: Biological functions and implication for disease diagnosis and vaccine design
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is transmitted by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has affected millions of …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has affected millions of …
A conserved oligomerization domain in the disordered linker of coronavirus nucleocapsid proteins
The nucleocapsid (N-) protein of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has a key role in viral assembly and scaffolding of the viral RNA. It promotes liquid …
CoV-2) has a key role in viral assembly and scaffolding of the viral RNA. It promotes liquid …
Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2
A Nguyen, H Zhao, D Myagmarsuren, S Srinivasan… - Elife, 2024 - elifesciences.org
Genetic diversity is a hallmark of RNA viruses and the basis for their evolutionary success.
Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the …
Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the …
The preference signature of the SARS-CoV-2 Nucleocapsid NTD for its 5'-genomic RNA elements
The nucleocapsid protein (N) of SARS-CoV-2 plays a pivotal role during the viral life cycle. It
is involved in RNA transcription and accounts for packaging of the large genome into virus …
is involved in RNA transcription and accounts for packaging of the large genome into virus …
RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid
AB Estelle, HM Forsythe, Z Yu, K Hughes… - PNAS …, 2023 - academic.oup.com
The nucleocapsid (N) protein of SARS-CoV-2 binds viral RNA, condensing it inside the
virion, and phase separating with RNA to form liquid–liquid condensates. There is little …
virion, and phase separating with RNA to form liquid–liquid condensates. There is little …
Structural dynamics of the SARS-CoV-2 spike protein: A 2-year retrospective analysis of SARS-CoV-2 variants (from Alpha to Omicron) reveals an early divergence …
We analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2 genomes.
The structural dynamics of these epitopes was determined by molecular modeling …
The structural dynamics of these epitopes was determined by molecular modeling …
RAGE is a receptor for SARS-CoV-2 N protein and mediates N protein–induced acute lung injury
J **a, J Wang, L Ying, R Huang, K Zhang… - American Journal of …, 2023 - atsjournals.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-
protein) increases early in body fluids during infection and has recently been identified as a …
protein) increases early in body fluids during infection and has recently been identified as a …
SARS-CoV-2 proteins monitored by long-range surface plasmon field-enhanced Raman scattering with hybrid bowtie nanoaperture arrays and nanocavities
X Luo, W Yue, S Zhang, H Liu, Z Chen, L Qiao, C Wu… - Lab on a Chip, 2023 - pubs.rsc.org
The identification of biomacromolecules by using surface-enhanced Raman scattering
(SERS) remains a challenge because of the near-field effect of traditional substrates. Long …
(SERS) remains a challenge because of the near-field effect of traditional substrates. Long …
Phase separation: the robust modulator of innate antiviral signaling and SARS-CoV-2 infection
Y Zheng, C Gao - Pathogens, 2023 - mdpi.com
SARS-CoV-2 has been a pandemic threat to human health and the worldwide economy, but
efficient treatments are still lacking. Type I and III interferons are essential for controlling viral …
efficient treatments are still lacking. Type I and III interferons are essential for controlling viral …