Cuproptosis: harnessing transition metal for cancer therapy

W Wang, W Mo, Z Hang, Y Huang, H Yi, Z Sun, A Lei - ACS nano, 2023 - ACS Publications
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Designing bioresponsive nanomaterials for intracellular self-assembly

S Chagri, DYW Ng, T Weil - Nature Reviews Chemistry, 2022 - nature.com
Supramolecular assemblies are essential components of living organisms. Cellular
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …

Fundamental mechanisms of regulated cell death and implications for heart disease

DP Del Re, D Amgalan, A Linkermann… - Physiological …, 2019 - journals.physiology.org
Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Understanding apoptosis and apoptotic pathways targeted cancer therapeutics

R Jan - Advanced pharmaceutical bulletin, 2019 - pmc.ncbi.nlm.nih.gov
Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

Mechanisms of biological effects of ionic liquids: from single cells to multicellular organisms

KS Egorova, AV Kibardin, AV Posvyatenko… - Chemical …, 2024 - ACS Publications
The review presents a detailed discussion of the evolving field studying interactions
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …

Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense

M Zheng, R Karki, P Vogel, TD Kanneganti - Cell, 2020 - cell.com
Caspases regulate cell death, immune responses, and homeostasis. Caspase-6 is
categorized as an executioner caspase but shows key differences from the other …

[HTML][HTML] Targeting apoptotic caspases in cancer

A Boice, L Bouchier-Hayes - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

[HTML][HTML] Cell death in the origin and treatment of cancer

A Strasser, DL Vaux - Molecular cell, 2020 - cell.com
Cell death, or, more specifically, cell suicide, is a process of fundamental importance to
human health. Throughout our lives, over a million cells are produced every second. When …

A long way to go: caspase inhibitors in clinical use

S Dhani, Y Zhao, B Zhivotovsky - Cell death & disease, 2021 - nature.com
Caspases are an evolutionary conserved family of cysteine-dependent proteases that are
involved in many vital cellular processes including apoptosis, proliferation, differentiation …

The TNF family of ligands and receptors: communication modules in the immune system and beyond

C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …