Recent developments in the use of kinase inhibitors for management of viral infections

R Raghuvanshi, SB Bharate - Journal of medicinal chemistry, 2021 - ACS Publications
Kinases are a group of therapeutic targets involved in the progression of numerous
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …

Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses

V Du Pont, RK Plemper, MJ Schnell - Current opinion in virology, 2019 - Elsevier
Rabies virus (RABV) constitutes a major social and economic burden associated with 60
000 deaths annually worldwide. Although pre-exposure and post-exposure treatment …

[HTML][HTML] Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-κB Signaling Pathways via TLR7

Y **e, Y Chi, X Tao, P Yu, Q Liu, M Zhang… - International Journal of …, 2024 - mdpi.com
Rabies is a fatal neurological infectious disease caused by rabies virus (RABV), which
invades the central nervous system (CNS). RABV with varying virulence regulates …

Reevaluation of the efficacy of favipiravir against rabies virus using in vivo imaging analysis

K Yamada, K Noguchi, K Kimitsuki, R Kaimori, N Saito… - Antiviral Research, 2019 - Elsevier
Rabies virus (RABV) is a highly neurotropic virus and the causative agent of rabies, an
encephalitis with an almost 100% case-fatality rate that remains incurable after the onset of …

[HTML][HTML] Assessing rabies vaccine protection against a novel lyssavirus, Kotalahti bat lyssavirus

R Shipley, E Wright, FZX Lean, D Selden, DL Horton… - Viruses, 2021 - mdpi.com
Rabies is a fatal encephalitis caused by an important group of viruses within the Lyssavirus
genus. The prototype virus, rabies virus, is still the most commonly reported lyssavirus and …

A One Medicine Mission for an Effective Rabies Therapy

DL Knobel, AC Jackson, J Bingham, HCJ Ertl… - Frontiers in Veterinary …, 2022 - frontiersin.org
Despite the disease's long history, little progress has been made toward a treatment for
rabies. The prognosis for patient recovery remains dire. For any prospect of survival, patients …

[HTML][HTML] Pyrimethamine inhibits rabies virus replication in vitro

S Rogée, F Larrous, D Jochmans, Y Ben-Khalifa… - Antiviral Research, 2019 - Elsevier
Rabies virus transmits from animals to humans and causes encephalitis. Every year more
than 15 million people receive a post exposure prophylaxis (PEP) treatment that is highly …

Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS

SP Smith, G Wu, AR Fooks, J Ma… - Journal of General …, 2019 - microbiologyresearch.org
Rabies virus causes an invariably fatal encephalitis following the onset of clinical disease.
Despite the availability of safe and effective vaccines, the clinical stages of rabies …

[HTML][HTML] BCX4430 inhibits the replication of rabies virus by suppressing mTOR-dependent autophagy in vitro

Y **e, YL Chi, SQ Liu, WY Zhu - Virology, 2023 - Elsevier
Rabies is a fatal neurological infectious disease caused by rabies virus (RABV). However,
no effective anti-RABV drugs for treatment during the symptomatic phase are available. The …

Dual role of toll-like receptor 7 in the pathogenesis of rabies virus in a mouse model

Z Luo, L Lv, Y Li, B Sui, Q Wu, Y Zhang, J Pei… - Journal of …, 2020 - journals.asm.org
Rabies, caused by rabies virus (RABV), is a fatal encephalitis in humans and other
mammals, which continues to present a public health threat in most parts of the world. Our …