We summarize, in this review, the evidence that genomic balance influences gene
expression, quantitative traits, dosage compensation, aneuploid syndromes, population …

Each mode of gene duplication (tandem, tetraploid, segmental, transpositional) retains
genes in a biased manner. A reciprocal relationship exists between plant genes retained …

Gene duplications have long been recognized as a contributor to the evolution of genes with
new functions. Multiple copies of genes can result from tandem duplication, from …

Heterosis refers to the phenomenon that progeny of diverse varieties of a species or crosses
between species exhibit greater biomass, speed of development, and fertility than both …

Changes in DNA copy number, whether confined to specific genes or affecting whole
chromosomes, have been identified as causes of diseases and developmental …

According to what we term the balance hypothesis, an imbalance in the concentration of the
subcomponents of a protein–protein complex can be deleterious. If so, there are two …

Many disease states result from gene overexpression, often in a specific genetic context. To
explore gene overexpression phenotypes systematically, we assembled an array of 5280 …

The development and application of genetic tools and resources has enabled a partial
genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis …

Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are
heterozygous for a loss-of-function allele. Despite its relevance to human disease, neither …

A change in chromosome number that is not the exact multiple of the haploid karyotype is
known as aneuploidy. This condition interferes with growth and development of an organism …