Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Temperature sensitive receptors in the skin and deep body enable the detection of the
external and internal environment, including the perception of thermal stimuli. Changes in …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

TRPA1 and TRPM8 are transient receptor potential channels expressed in trigeminal
neurons that are related to pathophysiology in migraine models. Here we use a mouse …

It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …

Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having
varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being …

Menthol in mints elicits coolness sensation by selective activation of TRPM8 ion channel.
Although structures of TRPM8 channel were determined by cryo-EM in the apo and liganded …