The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

Cancer genomics has revealed many genes and core molecular processes that contribute to
human malignancies, but the genetic and molecular bases of many rare cancers remains …

Alternative splicing of precursor mRNA is an important mechanism that increases
transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA …

Abstract tRNA are post-transcriptionally modified by chemical modifications that affect all
aspects of tRNA biology. An increasing number of mutations underlying human genetic …

Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …

Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic
information organized in mRNA codons, translating them into the code of 20 amino acids. To …

Over the course of more than two decades, natural products isolated from various
microorganisms and plants have built the foundation for chemical biology research into the …