Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Mitogen-activated protein kinases (MAPKs) have been the focus of many studies over the
past several decades, but the understanding of one subgroup of MAPKs, orthologs of …

Osteoarthritis (OA) is always characterized as excessive reactive oxygen species (ROS)
inside articular cavity. Mimicking natural metalloenzymes with metal ions as the active …

Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as
a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling …

Oxidation processes in mitochondria and different environmental insults contribute to
unwarranted accumulation of reactive oxygen species (ROS). These, in turn, rapidly damage …

oxoguanine (8-oxoG) based DNA damage is the most common type of DNA damage which
greatly affect gene expression. Therefore, accurate quantification of 8-oxoG based DNA …

Background Synovial hypoxia, a critical pathological characteristic of rheumatoid arthritis
(RA), significantly contributes to synovitis and synovial hyperplasia. In response to hypoxic …

Develo** probes for simultaneous diagnosis and killing of cancer cells is crucial, yet
challenging. This article presents the design and synthesis of a novel Rhodamine B …

The mitogen-activated protein kinase (MAPK) gene family performs crucial roles in cell
division, migration, development, apoptosis, inflammatory response, and abiotic and biotic …

Chronic exposure to environmental hazards causes airway epithelial dysfunction, primarily
impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of …