In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13
locus and/or mutation (s) within the TP53 gene, are associated with resistance to …

Introduction Genomic studies have allowed to identify molecular predictors for chronic
lymphocytic leukemia (CLL) treatment tailoring. TP53 disruption is the strongest predictor of …

In chronic lymphocytic leukemia (CLL), analysis of TP53 aberrations (deletion and/or
mutation) is a crucial part of treatment decision-making algorithms. Technological and …

Oxo-7, 8-dihydroguanine (OG) is the most common oxidative modification in chromosomal
DNA induced by reactive oxygen species (ROS). OG damage promotes telomere shortening …

Evidence indicates that there are significant alterations in gut microbiota diversity and
composition in patients with hematological malignancies. The present study investigated the …

The mutational status of the IGHV gene is routinely assessed in patients with chronic
lymphocytic leukaemia (CLL), since it is both prognostic of clinical outcome and predictive of …

Background Taxonomic identification of plants and insects is a hard process that demands
expert taxonomists and time, and it's often difficult to distinguish on morphology only. DNA …

In the era of next generation sequencing and beyond, the Sanger technique is still widely
used for variant verification of inconclusive or ambiguous high-throughput sequencing …

Sequencing of a Polymerase Chain Reaction product (amplicon) is called amplicon
sequencing. Amplicon sequencing allows for reliable identification of an organism by …

DNA sequencing as primary means for analyzing genomic data is a continually advancing
set of methods. The more recent methods of DNA sequencing producing large quantities of …