Non-motor features of Parkinson disease

AHV Schapira, KR Chaudhuri, P Jenner - Nature Reviews …, 2017 - nature.com
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Evidence for early and regular physical therapy and exercise in Parkinson's disease

TD Ellis, C Colón-Semenza, TR DeAngelis… - Seminars in …, 2021 - thieme-connect.com
Advances in medical management of Parkinson's disease (PD) have resulted in living
longer with disability. Although disability worsens over the course of the disease, there are …

Parkinson's disease symptoms: the patient's perspective

M Politis, K Wu, S Molloy, P G. Bain… - Movement …, 2010 - Wiley Online Library
Patients suffering from Parkinson's disease (PD) will typically experience a range of motor
and nonmotor symptoms during the course of their illness, each of which will affect a …

Applications of brain organoids in neurodevelopment and neurological diseases

N Sun, X Meng, Y Liu, D Song, C Jiang… - Journal of Biomedical …, 2021 - Springer
A brain organoid is a self-organizing three-dimensional tissue derived from human
embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and …

Pathophysiology of somatosensory abnormalities in Parkinson disease

A Conte, N Khan, G Defazio, JC Rothwell… - Nature Reviews …, 2013 - nature.com
Abstract Changes in sensory function that have been described in patients with Parkinson
disease (PD) can be either'pure'disorders of conscious perception such as elevations in …

Gender-related differences in the burden of non-motor symptoms in Parkinson's disease

P Martinez-Martin, C Falup Pecurariu, P Odin… - Journal of …, 2012 - Springer
Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD)
patients may have important implications for their management and prognosis. Gender is a …

Neurological diseases and pain

D Borsook - Brain, 2012 - academic.oup.com
Chronic pain is a frequent component of many neurological disorders, affecting 20–40% of
patients for many primary neurological diseases. These diseases result from a wide range of …

Diagnosis and management of Parkinson's disease

A Tarakad, J Jankovic - Seminars in neurology, 2017 - thieme-connect.com
Despite numerous efforts to identify specific and sensitive biomarkers, the diagnosis of
Parkinson's disease (PD) is still based on clinical criteria that include the presence of a …

Pains in Parkinson disease—many syndromes under one umbrella

G Wasner, G Deuschl - Nature Reviews Neurology, 2012 - nature.com
Pain is a nonmotor symptom that substantially affects the quality of life of at least one-third of
patients with Parkinson disease (PD). Interestingly, patients with PD frequently report …

The progression of non-motor symptoms in Parkinson's disease and their contribution to motor disability and quality of life

A Antonini, P Barone, R Marconi, L Morgante… - Journal of …, 2012 - Springer
Non-motor symptoms are gaining relevance in Parkinson's disease (PD) management but
little is known about their progression and contribution to deterioration of quality of life. We …