Environmental and health impacts of graphene and other two-dimensional materials: a graphene flagship perspective

H Lin, T Buerki-Thurnherr, J Kaur, P Wick, M Pelin… - ACS …, 2024 - ACS Publications
Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation
of atomically thin sheets of graphene in 2004 due to the specific and versatile properties of …

Understanding the chemical exposome during fetal development and early childhood: a review

M Krausová, D Braun… - Annual Review of …, 2023 - annualreviews.org
Early human life is considered a critical window of susceptibility to external exposures.
Infants are exposed to a multitude of environmental factors, collectively referred to as the …

Trophoblast stem cell-based organoid models of the human placental barrier

T Hori, H Okae, S Shibata, N Kobayashi… - Nature …, 2024 - nature.com
Human placental villi have essential roles in producing hormones, mediating nutrient and
waste exchange, and protecting the fetus from exposure to xenobiotics. Human trophoblast …

3D in vitro blood‐brain‐barrier model for investigating barrier insults

W Wei, F Cardes, A Hierlemann… - Advanced …, 2023 - Wiley Online Library
Abstract Blood‐brain‐barrier (BBB) disruption has been associated with a variety of central‐
nervous‐system diseases. In vitro BBB models enable to investigate how the barrier reacts …

Revolutionizing the female reproductive system research using microfluidic chip platform

J Yan, T Wu, J Zhang, Y Gao, JM Wu… - Journal of …, 2023 - Springer
Comprehensively understanding the female reproductive system is crucial for safeguarding
fertility and preventing diseases concerning women's health. With the capacity to simulate …

Placenta-on-a-chip as an in vitro approach to evaluate the physiological and structural characteristics of the human placental barrier upon drug exposure: a systematic …

FA Elzinga, B Khalili, DJ Touw, JR Prins… - Journal of Clinical …, 2023 - mdpi.com
Quantification of fetal drug exposure remains challenging since sampling from the placenta
or fetus during pregnancy is too invasive. Currently existing in vivo (eg, cord blood sampling) …

Advances in cell coculture membranes recapitulating in vivo microenvironments

J Yoo, Y Jung, K Char, Y Jang - Trends in Biotechnology, 2023 - cell.com
Porous membranes play a critical role in in vitro heterogeneous cell coculture systems
because they recapitulate the in vivo microenvironment to mediate physical and biochemical …

[HTML][HTML] Investigating and modelling an engineered millifluidic in vitro oocyte maturation system reproducing the physiological ovary environment in the sheep model

A Mastrorocco, L Cacopardo, L Temerario, NA Martino… - Cells, 2022 - mdpi.com
In conventional assisted reproductive technologies (ARTs), oocytes are in vitro cultured in
static conditions. Instead, dynamic systems could better mimic the physiological in vivo …

RISING STARS: Approaches to modeling placental function in preeclampsia in vitro and in vivo

J Milano-Foster, LC Schulz - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Modeling preeclampsia remains difficult due to the nature of the disease and the unique
characteristics of the human placenta. Members of the Hominidae superfamily have a villous …

Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles

M Abdelkarim, L Perez-Davalos… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Organ-on-a-chip (OOC) models are based on microfluidics and can recapitulate
the healthy and diseased microstructure of organs1 and tissues and the dynamic …