The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Renewal of the intestinal epithelium occurs approximately every week and requires a careful
balance between cell proliferation and differentiation to maintain proper lineage ratios and …

Notch signaling can have either an oncogenic or tumor-suppressive function in cancer
depending on the cancer type and cellular context. While Notch can be oncogenic in early …

Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against
the microbiota, as well as a conduit for signaling between the microbiota and systemic host …

Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via
promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the …

Alterations in intestinal structure, mechanics and physiology underlie acute and chronic
intestinal conditions, many of which are influenced by dysregulation of microbiome …

Cancer biology research over recent decades has given ample evidence for the existence of
self-renewing and drug-resistant populations within heterogeneous tumors, widely …

Disruption of the intestinal barrier is both the cause and result of sepsis. The proliferation
and differentiation of intestinal stem cells (ISCs) promote the regenerative nature of intestinal …

The intestine is home to trillions of microorganisms, and the vast diversity within this gut
microbiota exists in a balanced state to protect the intestinal mucosal barrier. Research into …

Dynamic changes in cell properties lead to intratumor heterogeneity; however, the
mechanisms of nongenetic cellular plasticity remain elusive. When the fate of each cell from …