Adrenal insufficiency (AI) is a serious condition, which can arise from pathology affecting the
adrenal gland itself (primary adrenal insufficiency, PAI), hypothalamic or pituitary pathology …

In recent years, the need for centers of excellence (COEs), for patients to receive the most
innovative diagnostic work-up and best medical care, has become increasingly urgent …

Objective: The objective of this Disease State Clinical Review is to provide clinicians with a
practical approach to the evaluation of incidentally discovered adrenal masses. Methods: A …

Cushing's disease recurrence following successful pituitary surgery is common and merits
prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity …

The proper clinical evaluation of pituitary and adrenal disorders depends on the accurate
measurement of plasma ACTH. The modern two-site sandwich ACTH immunoassay is a …

The evaluation of suspected hypercortisolism is one of the most challenging problems in
medicine. The signs and symptoms described by Dr Harvey Cushing are common and often …

Accurate classification of postsurgical remission, and early recognition of recurrence are
crucial to timely treat and prevent excess mortality in Cushing's Disease, yet the criteria used …

BACKGROUND Measurement of plasma adrenocorticotropic hormone (ACTH) is key in the
differential diagnosis of hypothalamic-pituitary-adrenal disorders. Two-site sandwich …

Biochemical confirmation of a diagnosis of hypercortisolism (Cushing syndrome) is vital to
direct further investigations, especially given the overlap with non-autonomous conditions …

Glucocorticoids modulate glucose homeostasis, acting on metabolically active tissues such
as liver, skeletal muscle, and adipose tissue. Intracellular regulation of glucocorticoid action …