Potential resistance of SARS-CoV-2 main protease (Mpro) against protease inhibitors: lessons learned from HIV-1 protease
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2
(SARS-CoV-2), has been one of the most devastating pandemics of recent times. The lack of …
(SARS-CoV-2), has been one of the most devastating pandemics of recent times. The lack of …
Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel
MS Hirsch, HF Günthard, JM Schapiro… - Clinical Infectious …, 2008 - academic.oup.com
Resistance to antiretroviral drugs remains an important limitation to successful human
immunodeficiency virus type 1 (HIV-1) therapy. Resistance testing can improve treatment …
immunodeficiency virus type 1 (HIV-1) therapy. Resistance testing can improve treatment …
Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a …
Background The effect of transmitted drug resistance (TDR) on first-line combination
antiretroviral therapy (cART) for HIV-1 needs further study to inform choice of optimum drug …
antiretroviral therapy (cART) for HIV-1 needs further study to inform choice of optimum drug …
Flexible parametric models for relative survival, with application in coronary heart disease
Relative survival is frequently used in population‐based studies as a method for estimating
disease‐related mortality without the need for information on cause of death. We propose an …
disease‐related mortality without the need for information on cause of death. We propose an …
Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a …
Background The effect of pretreatment HIV-1 drug resistance on the response to first-line
combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed. We …
combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed. We …
[PDF][PDF] European recommendations for the clinical use of HIV drug resistance testing: 2011 update
Abstract The European HIV Drug Resistance Guidelines Panel, established to make
recommendations to clinicians and virologists, felt that sufficient new information has …
recommendations to clinicians and virologists, felt that sufficient new information has …
Preexisting resistance to nonnucleoside reverse-transcriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1–infected …
DR Kuritzkes, CM Lalama, HJ Ribaudo… - The Journal of …, 2008 - academic.oup.com
A case-cohort study was used to determine the effect of baseline nonnucleoside reverse-
transcriptase inhibitor (NNRTI) resistance, as assessed by viral genoty**, on the response …
transcriptase inhibitor (NNRTI) resistance, as assessed by viral genoty**, on the response …
A novel methodology for large-scale phylogeny partition
Understanding the determinants of virus transmission is a fundamental step for effective
design of screening and intervention strategies to control viral epidemics. Phylogenetic …
design of screening and intervention strategies to control viral epidemics. Phylogenetic …
Doravirine suppresses common nonnucleoside reverse transcriptase inhibitor-associated mutants at clinically relevant concentrations
M Feng, NA Sachs, M Xu, J Grobler… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Doravirine (DOR), which is currently in a phase 3 clinical trial, is a novel human
immunodeficiency type 1 virus (HIV-1) nonnucleoside reverse transcriptase inhibitor …
immunodeficiency type 1 virus (HIV-1) nonnucleoside reverse transcriptase inhibitor …
Transmission of HIV-1 drug resistance in Switzerland: a 10-year molecular epidemiology survey
S Yerly, V von Wyl, B Ledergerber, J Böni… - Aids, 2007 - journals.lww.com
Objectives: Representative prevalence data of transmitted drug-resistant HIV-1 are essential
to establish accurate guidelines addressing resistance testing and first-line treatments …
to establish accurate guidelines addressing resistance testing and first-line treatments …