Dementia is a syndrome associated with a wide range of clinical features including
progressive cognitive decline and patient inability to self-care. Due to rapidly increasing …

Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …

Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS),
exert a pivotal influence on brain development, homeostasis, and functionality …

Data-independent acquisition (DIA)-mass spectrometry (MS)-based proteomic analysis
overtop the existing data-dependent acquisition (DDA)-MS-based proteomic analysis to …

The vast majority of human tissue specimens are formalin-fixed, paraffin embedded (FFPE)
archival samples, making this type of tissue a potential gold mine for medical research. It is …

Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate
cellular processes including cellular senescence, telomere shortening, stem cell exhaustion …

The complex pathology of Alzheimer's disease (AD) emphasises the need for
comprehensive modelling of the disease, which may lead to the development of efficient …

The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine
tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory …

In genome-wide association studies, detecting high-order epistasis is important for
analyzing the occurrence of complex human diseases and explaining missing heritability …

There is growing genetic and proteomic data highlighting the complexity of Alzheimer's
disease (AD) pathogenesis. Greater use of unbiased “omics” approaches is being …