Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are
widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain …

Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling
pathway in the cardiovascular system. The peptide is a potent inotropic agent and …

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …

Background—To assess cardiovascular actions of APJ agonism during prolonged (Pyr1)
apelin-13 infusion and renin–angiotensin system activation. Methods and Results—Forty …

Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key
hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …

Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms
characterized by different numbers of amino acids. The number of amino acids in the active …

Apelin is an endogenous peptide ligand for the G protein-coupled receptor
APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts …