Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

MHC class II molecules on the surface of antigen-presenting cells display a range of
peptides for recognition by the T-cell receptors of CD4+ T helper cells. Therefore, MHC class …

Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …

Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases,
but the antigens that stimulate their responses have been difficult to identify and in most …

At least 20 different chromosomal regions have been linked to type 1 diabetes (T1D)
susceptibility in humans, using genome screening, candidate gene testing, and studies of …

Starting with early crucial discoveries of the role of the major histocompatibility complex,
genetic studies have long had a role in understanding the biology of type 1 diabetes (T1D) …

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2
in humans and IA g7 in nonobese diabetic (NOD) mice are the major risk factors for …

Abstract Forkhead box P3 (FOXP3)-expressing regulatory T (TReg) cells have a pivotal role
in the regulation of immune responses and in the maintenance of immunological self …

Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …