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[HTML][HTML] Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review
DB Fogel - Contemporary clinical trials communications, 2018 - Elsevier
Clinical trials are time consuming, expensive, and often burdensome on patients. Clinical
trials can fail for many reasons. This survey reviews many of these reasons and offers …
trials can fail for many reasons. This survey reviews many of these reasons and offers …
Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities
Background Despite significant investment in infrastructure many trials continue to face
challenges in recruitment and retention. We argue that insufficient focus has been placed on …
challenges in recruitment and retention. We argue that insufficient focus has been placed on …
Dynamic consent: a potential solution to some of the challenges of modern biomedical research
I Budin-Ljøsne, HJA Teare, J Kaye, S Beck… - BMC medical …, 2017 - Springer
Background Innovations in technology have contributed to rapid changes in the way that
modern biomedical research is carried out. Researchers are increasingly required to …
modern biomedical research is carried out. Researchers are increasingly required to …
Prevalence, characteristics, and publication of discontinued randomized trials
Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs …
and often wastes scarce research resources. The epidemiology of discontinued RCTs …
Optimising recruitment and informed consent in randomised controlled trials: the development and implementation of the Quintet Recruitment Intervention (QRI)
Background Pragmatic randomised controlled trials (RCTs) are considered essential to
determine effective interventions for routine clinical practice, but many fail to recruit …
determine effective interventions for routine clinical practice, but many fail to recruit …
Increasing value and reducing waste in biomedical research regulation and management
After identification of an important research question and selection of an appropriate study
design, waste can arise from the regulation, governance, and management of biomedical …
design, waste can arise from the regulation, governance, and management of biomedical …
Community engagement and ethical global health research
Community engagement is increasingly recognized as a critical element of medical
research, recommended by ethicists, required by research funders and advocated in ethics …
research, recommended by ethicists, required by research funders and advocated in ethics …
The ROAM/EORTC-1308 trial: radiation versus observation following surgical resection of atypical meningioma: study protocol for a randomised controlled trial
Background Atypical meningiomas are an intermediate grade brain tumour with a
recurrence rate of 39–58%. It is not known whether early adjuvant radiotherapy reduces the …
recurrence rate of 39–58%. It is not known whether early adjuvant radiotherapy reduces the …
Factors that impact on recruitment to randomised trials in health care: a qualitative evidence synthesis
Background Randomised trials (also referred to as 'randomised controlled trials' or 'trials')
are the optimal way to minimise bias in evaluating the effects of competing treatments …
are the optimal way to minimise bias in evaluating the effects of competing treatments …
Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease: diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological …
The differential diagnosis of Creutzfeldt-Jakob disease (CJD) from other, sometimes
treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity …
treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity …