Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

The α1A-adrenergic receptor (α1AAR) belongs to the family of G protein-coupled receptors
that respond to adrenaline and noradrenaline. α1AAR is involved in smooth muscle …

G protein-coupled receptors signal through a variety of mechanisms that impact cardiac
function, including contractility and hypertrophy. G protein–dependent and G protein …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

α1‐Adrenoceptors are seven transmembrane domain GPCRs involved in numerous
physiological functions controlled by the endogenous catecholamines, noradrenaline and …

Depression is a serious global illness, becoming more and more common in developed
countries. Because of specific symptoms it is considered as a leading cause of disability all …

This review examines the functions of α 1-adrenoceptor subtypes, particularly in terms of
contraction of smooth muscle. There are 3 subtypes of α 1-adrenoceptor, α 1A-α 1B-and α …

Cone snails have evolved many 1000s of small, structurally stable venom peptides
(conopeptides) for prey capture and defense. Whilst< 0.1% have been pharmacologically …

Atherosclerosis is characterized by the narrowing of the arterial lumen due to subendothelial
lipid accumulation, with hypercholesterolemia being a major risk factor. Despite the recent …