Acute kidney injury in critically ill patients with COVID-19

P Gabarre, G Dumas, T Dupont, M Darmon… - Intensive care …, 2020 - Springer
Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-
CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with …

Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms

E Ahmadian, SM Hosseiniyan Khatibi… - Reviews in medical …, 2021 - Wiley Online Library
The novel coronavirus (SARS‐CoV‐2) has turned into a life‐threatening pandemic disease
(Covid‐19). About 5% of patients with Covid‐19 have severe symptoms including septic …

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

S Pons, S Fodil, E Azoulay, L Zafrani - Critical care, 2020 - Springer
In severe SARS-CoV-2 infections, emerging data including recent histopathological studies
have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction …

IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19

T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

[HTML][HTML] Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

K Golebski, JA Layhadi, U Sahiner, EH Steveling-Klein… - Immunity, 2021 - cell.com
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to
the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Blood-brain barrier dysfunction and recovery after ischemic stroke

X Jiang, AV Andjelkovic, L Zhu, T Yang… - Progress in …, 2018 - Elsevier
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Endothelial dysfunction in Covid-19 infection

HM Otifi, BK Adiga - The American journal of the medical sciences, 2022 - Elsevier
COVID-19 is an evolving systemic inflammatory pandemic disease, predominantly affecting
the respiratory system. Associated cardiovascular comorbid conditions result in severe to …

Immunotherapeutic implications of IL-6 blockade for cytokine storm

T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Taylor & Francis
IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …