Emerging data point to important contributions of both autoimmune inflammation and
progressive degeneration in the pathophysiology of multiple sclerosis (MS). Unfortunately …

Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the
magnetization transfer (MT) effect and defined as a relative amount of protons bound to …

Myelin-sensitive MRI such as magnetization transfer imaging has been widely used in
multiple sclerosis. The influence of methodology and differences in disease subtype on …

Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS),
caused by the accrual of brain structural damage only partially counteracted by effective …

Background Cognitive impairment is one of the concerns of Multiple Sclerosis (MS) and has
been related to myelin loss. Different neuroimaging methods have been used to quantify …

A sensitive and efficient imaging technique is required to assess the subtle abnormalities
occurring in the normal-appearing white matter (NAWM) and normal-appearing grey matter …

Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) can
probe tissue biochemistry in vivo with high resolution and sensitivity without requiring …

Set during the Annual Meeting of the International Society for Magnetic Resonance in
Medicine (ISMRM), the “Clinical Focus Meeting”(CFM) aims to bridge the gap between …

Selective inversion recovery (SIR) is a quantitative magnetization transfer (qMT) method that
provides estimates of parameters related to myelin content in white matter, namely the …

Purpose In MRI, the macromolecular proton fraction (MPF) is a key parameter of
magnetization transfer (MT). It represents the relative amount of immobile protons …