Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

T cell expansion and memory formation are generally more effective when elicited by live
organisms than by inactivated vaccines. Elucidation of the underlying mechanisms is …

The interface between an infectious agent and its host represents the ultimate battleground
for survival: The microbe must secure a niche for replication, whereas the host must limit the …

Abstract Interferon-β (IFN-β) is the major treatment for multiple sclerosis. However, this
treatment is not always effective. Here we have found congruence in outcome between …

Certain forms of hexavalent chromium [Cr (VI)] are known respiratory carcinogens that
induce a broad spectrum of DNA damage. Cr (VI)-carcinogenesis may be initiated or …

We found upregulation of expression of the microRNA miR-155 in primary effector and
effector memory CD8+ T cells, but low miR-155 expression in naive and central memory …

The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular
functions. The major signaling pathway activated by type I IFNs involves sequential …

Cannabinoids have been shown to exert anti-inflammatory activities in various in vivo and in
vitro experimental models as well as ameliorate various inflammatory degenerative …