Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
In silico approaches to identify polyphenol compounds as α-glucosidase and α-amylase inhibitors against type-II diabetes
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors,
and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α …
and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α …
Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors
S Moghadam Farid, M Noori, M Nazari Montazer… - Scientific Reports, 2023 - nature.com
In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed,
synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most …
synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most …
[HTML][HTML] Quinoline derivatives as possible lead compounds for anti-malarial drugs: Spectroscopic, DFT and MD study
In this work we report spectroscopic characterization and reactivity study by density
functional theory (DFT) and molecular dynamics (MD) simulations of two quinoline …
functional theory (DFT) and molecular dynamics (MD) simulations of two quinoline …
Design, synthesis, and in silico studies of quinoline-based-benzo [d] imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
M Noori, A Davoodi, A Iraji, N Dastyafteh, M Khalili… - Scientific Reports, 2022 - nature.com
In this study, 18 novel quinoline-based-benzo [d] imidazole derivatives were synthesized
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
Design, synthesis, in vitro, and in silico enzymatic evaluations of thieno [2, 3-b] quinoline-hydrazones as novel inhibitors for α-glucosidase
M Noori, M Rastak, M Halimi, MK Ghomi… - Bioorganic …, 2022 - Elsevier
In the development of novel anti-α-glucosidase agents, we synthesized novel thieno [2, 3-b]
quinoline-hydrazones 9a-n by facile and efficient conventional chemical reactions. These …
quinoline-hydrazones 9a-n by facile and efficient conventional chemical reactions. These …
Novel polyhydroquinoline Schiff's base derivatives: synthesis, characterization, in vitro α-glucosidase inhibitory, and molecular docking studies
Novel Schiff's base hydrazone derivatives (1–24) based on polyhydroquinoline (PHQ) were
synthesized in good to excellent yields via three step reactions. Compound 1 (starting …
synthesized in good to excellent yields via three step reactions. Compound 1 (starting …
Quinoline-based Schiff bases as possible antidiabetic agents: ligand-based pharmacophore modeling, 3D QSAR, docking, and molecular dynamics simulations study
SD Ranade, SG Alegaon, NA Khatib, S Gharge… - RSC medicinal …, 2024 - pubs.rsc.org
α-Glucosidase enzyme inhibition is a legitimate approach to combat type 2 diabetes mellitus
as it manages to control postprandial hyperglycemia. In this pursuit, a literature search …
as it manages to control postprandial hyperglycemia. In this pursuit, a literature search …
Synthesis of benzothiazole derivatives as a potent α-glucosidase inhibitor
Diabetes is one of the pre-dominant metabolic disorders all over the world. It is the prime
reason of mortality and morbidity due to hyperglycemia which is link with numerus obstacles …
reason of mortality and morbidity due to hyperglycemia which is link with numerus obstacles …
Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies
Abstract A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl aryl ether derivatives (1−
2 3) were synthesized and characterized by EI-MS and 1 H NMR, and screened for their α …
2 3) were synthesized and characterized by EI-MS and 1 H NMR, and screened for their α …