Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability,,–
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …

BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …

High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to
the limited effectiveness of existing chemo-and immunotherapies. To elucidate mechanisms …

Despite advances in immuno-oncology, the relationship between tumor genotypes and
response to immunotherapy remains poorly understood, particularly in high-grade serous …

Three-dimensional cancer organoids derived from self-organizing cancer stems are ex vivo
miniatures of tumors that faithfully recapitulate their structure, distinctive cancer features, and …

High-grade serous ovarian cancer (HGSOC) is a lethal malignancy characterized by an
immunosuppressive tumor microenvironment containing few tumor infiltrating lymphocytes …

Gene editing has great potential in treating diseases caused by well-characterized
molecular alterations. The introduction of clustered regularly interspaced short palindromic …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and develo** therapies. Here, we review …