Key genes and convergent pathogenic mechanisms in Parkinson disease
Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …
Gaucher disease provides a unique window into Parkinson disease pathogenesis
E Hertz, Y Chen, E Sidransky - Nature Reviews Neurology, 2024 - nature.com
An exciting development in the field of neurodegeneration is the association between the
rare monogenic disorder Gaucher disease and the common complex disorder Parkinson …
rare monogenic disorder Gaucher disease and the common complex disorder Parkinson …
Stay in touch with the endoplasmic reticulum
S Sun, G Zhao, M Jia, Q Jiang, S Li, H Wang… - Science China Life …, 2024 - Springer
The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and
sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it …
sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it …
VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons
Loss-of-function mutations in VPS13C are linked to early-onset Parkinson's disease (PD).
While VPS13C has been previously studied in non-neuronal cells, the neuronal role of …
While VPS13C has been previously studied in non-neuronal cells, the neuronal role of …
The endoplasmic reticulum and its contacts: Emerging roles in axon development, neurotransmission, and degeneration
The neuronal endoplasmic reticulum (ER) consists of a dynamic, tubular network that
extends all the way from the soma into dendrites, axons, and synapses. This morphology …
extends all the way from the soma into dendrites, axons, and synapses. This morphology …
[HTML][HTML] Neuronal endoplasmic reticulum architecture and roles in axonal physiology
K Yperman, M Kuijpers - Molecular and Cellular Neuroscience, 2023 - Elsevier
The endoplasmic reticulum (ER) is the largest membrane compartment within eukaryotic
cells and is emerging as a key coordinator of many cellular processes. The ER can …
cells and is emerging as a key coordinator of many cellular processes. The ER can …
IP3R at ER-Mitochondrial Contact Sites: Beyond the IP3R-GRP75-VDAC1 Ca2+ Funnel
P Atakpa-Adaji, A Ivanova - Contact, 2023 - journals.sagepub.com
Membrane contact sites (MCS) circumvent the topological constraints of functional coupling
between different membrane-bound organelles by providing a means of communication and …
between different membrane-bound organelles by providing a means of communication and …
Misregulation of mitochondria–lysosome contact dynamics in Charcot–Marie–Tooth Type 2B disease Rab7 mutant sensory peripheral neurons
Inter-organelle contact sites between mitochondria and lysosomes mediate the crosstalk
and bidirectional regulation of their dynamics in health and disease. However, mitochondria …
and bidirectional regulation of their dynamics in health and disease. However, mitochondria …
Nano‐Biointeractions of Functional Nanomaterials: The Emerging Role of Inter‐Organelle Contact Sites, Targeting, and Signaling
The study of nano‐biointeractions, at the forefront of interdisciplinary research, unveils
intricate interplays between nanomaterials (NMs) and intracellular organelles, which are …
intricate interplays between nanomaterials (NMs) and intracellular organelles, which are …
Imaging and proteomics toolkits for studying organelle contact sites
Organelle contact sites are regions where two heterologous membranes are juxtaposed by
molecular tethering complexes. These contact sites are important in inter-organelle …
molecular tethering complexes. These contact sites are important in inter-organelle …