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The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex
A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …
addiction has extended the scope of inquiry from the putative reward-related subcortical …
The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course
The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-
directed behaviors and displays remarkable structural and functional plasticity over the life …
directed behaviors and displays remarkable structural and functional plasticity over the life …
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …
from disruption of subcortical reward circuits. However, imaging studies in addictive …
Experience-dependent structural synaptic plasticity in the mammalian brain
Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of
existing synapses as well as structural plasticity, including synapse formation and …
existing synapses as well as structural plasticity, including synapse formation and …
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
OBJECTIVE: Studies of the neurobiological processes underlying drug addiction primarily
have focused on limbic subcortical structures. Here the authors evaluated the role of frontal …
have focused on limbic subcortical structures. Here the authors evaluated the role of frontal …
The neural basis of addiction: a pathology of motivation and choice
OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering
motivational strength and decreased ability to control the desire to obtain drugs. In this …
motivational strength and decreased ability to control the desire to obtain drugs. In this …
The reinstatement model of drug relapse: history, methodology and major findings
Rational and objectives. The reinstatement model is currently used in many laboratories to
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …
[كتاب][B] Addiction: A disorder of choice
GM Heyman - 2009 - degruyter.com
In a book sure to inspire controversy, Gene Heyman argues that conventional wisdom about
addiction—that it is a disease, a compulsion beyond conscious control—is wrong. At the …
addiction—that it is a disease, a compulsion beyond conscious control—is wrong. At the …
Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections
Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …