Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation

C Mazziotta, G Badiale, CF Cervellera… - …, 2024 - pmc.ncbi.nlm.nih.gov
Human osteogenic differentiation is a complex and well-orchestrated process which
involves a plethora of molecular players and cellular processes. A growing number of …

[HTML][HTML] SARS-CoV-2 infection: new molecular, phylogenetic, and pathogenetic insights. Efficacy of current vaccines and the potential risk of variants

JC Rotondo, F Martini, M Maritati, C Mazziotta… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered
coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 …

[HTML][HTML] Advanced molecular and immunological diagnostic methods to detect SARS-CoV-2 infection

JC Rotondo, F Martini, M Maritati, E Caselli… - Microorganisms, 2022 - mdpi.com
Simple Summary COVID-19 emerged in late 2019 in China and rapidly spread across the
globe. After 2 years, numerous advances have been made. First of all, the preventive …

Cancer biology and molecular genetics of A3 adenosine receptor

C Mazziotta, JC Rotondo, C Lanzillotti, G Campione… - Oncogene, 2022 - nature.com
Abstract A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to
be overexpressed in a large number of cancer types. This receptor plays an important role in …

[HTML][HTML] The role of purinergic P2X7 receptor in inflammation and cancer: novel molecular insights and clinical applications

JC Rotondo, C Mazziotta, C Lanzillotti, C Stefani… - Cancers, 2022 - mdpi.com
Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …

Frequency, morbidity and equity—the case for increased research on male fertility

S Kimmins, RA Anderson, CLR Barratt… - Nature Reviews …, 2024 - nature.com
Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

MicroRNA dysregulations in Merkel cell carcinoma: Molecular mechanisms and clinical applications

C Mazziotta, CF Cervellera, C Lanzillotti… - Journal of Medical …, 2023 - Wiley Online Library
Merkel cell carcinoma (MCC) is an aggressive skin malignancy with two distinct etiologies.
The first, which accounts for the highest proportion, is caused by Merkel cell polyomavirus …

Molecular markers: a new paradigm in the prediction of sperm freezability

M Ďuračka, F Benko, E Tvrdá - International journal of molecular sciences, 2023 - mdpi.com
For decades now, sperm cryopreservation has been a pillar of assisted reproduction in
animals as well as humans. Nevertheless, the success of cryopreservation varies across …

[HTML][HTML] Paternal age matters: Association with sperm criteria's-spermatozoa DNA integrity and methylation profile

M Lahimer, D Montjean, R Cabry, S Capelle… - Journal of Clinical …, 2023 - mdpi.com
Advanced age has been reported to negatively affect sperm parameters and spermatozoa
DNA integrity. A decline in sperm criteria was also associated with altered epigenetic marks …

Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction

G Sudhakaran, D Kesavan, K Kandaswamy… - Reproductive …, 2024 - Elsevier
Male infertility is a multifactorial condition influenced by epigenetic regulation, oxidative
stress, and mitochondrial dysfunction. Oxidative stress-induced damage leads to epigenetic …