Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Abstract Mediator complex subunit 12 (MED12) is the most frequently mutated gene in
uterine leiomyomas (ULs)—with a frequency of up to 85%—suggesting that it plays key roles …

Leiomyomas associated with hereditary leiomyomatosis and renal cell carcinoma syndrome
and leiomyomas with bizarre nuclei often show overlap** morphological features, in …

Uterine leiomyomas are the most common tumor of reproductive-age women worldwide.
Although benign, uterine fibroids cause significant morbidity and adversely impact the …

Context Mutations in the gene encoding Mediator complex subunit MED12 are dominant
drivers of uterine fibroids (UFs) in women of diverse racial and ethnic origins. Previously, we …

Uterine leiomyomas (ULs) are the most common gynecological benign tumors originating
from the myometrium. Prevalent mutations in the mediator complex subunit 12 (MED12) …

Purpose: Molecular studies have demonstrated a wide range of gene expression variations
in uterine leiomyoma. The rat sarcoma virus/rapidly accelerated fibrosarcoma/mitogen …

Multiple large-scale epidemiological studies have identified obesity as an important risk
factor for a variety of human cancers, particularly cancers of the uterus, gallbladder, kidney …

Objective: Paraoxonase 1 (PON1) plays a defensive role against oxidative stress by
destroying oxidized lipids. Q192R single nucleotide polymorphism of PON1 gene alters the …

Background: CYP19A1 gene encodes aromatase, a microsomal key enzyme that catalyzes
the synthesis of estrogens from androgens. Accumulating evidence has revealed that …