Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis

Y Li, J Wang, L Li, W Song, M Li, X Hua, Y Wang… - Natural product …, 2023 - pubs.rsc.org
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …

A review of the microbial production of bioactive natural products and biologics

JV Pham, MA Yilma, A Feliz, MT Majid… - Frontiers in …, 2019 - frontiersin.org
A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Emerging technologies in algal biotechnology: toward the establishment of a sustainable, algae-based bioeconomy

M Fabris, RM Abbriano, M Pernice… - Frontiers in plant …, 2020 - frontiersin.org
Mankind has recognized the value of land plants as renewable sources of food, medicine,
and materials for millennia. Throughout human history, agricultural methods were …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural product reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

Strategies to diversify natural products for drug discovery

G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

PD Sonawane, J Pollier, S Panda, J Szymanski… - Nature plants, 2016 - nature.com
The amount of cholesterol made by many plants is not negligible. Whereas
cholesterogenesis in animals was elucidated decades ago, the plant pathway has remained …

De novo production of the plant-derived alkaloid strictosidine in yeast

S Brown, M Clastre, V Courdavault… - Proceedings of the …, 2015 - pnas.org
The monoterpene indole alkaloids are a large group of plant-derived specialized
metabolites, many of which have valuable pharmaceutical or biological activity. There are∼ …

Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis

W Sun, Q Yin, H Wan, R Gao, C **ong, C **e… - Nature …, 2023 - nature.com
Horse chestnut (Aesculus chinensis) is an important medicinal tree that contains various
bioactive compounds, such as aescin, barrigenol-type triterpenoid saponins (BAT), and …

Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency

P Wang, W Wei, W Ye, X Li, W Zhao, C Yang, C Li… - Cell discovery, 2019 - nature.com
Synthetic biology approach has been frequently applied to produce plant rare bioactive
compounds in microbial cell factories by fermentation. However, to reach an ideal …