From an engineering perspective, skeletal tissues are remarkable structures because they
are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical …

As the application of Raman spectroscopy to study bone has grown over the past decade,
making it a peer technology to FTIR spectroscopy, it has become critical to understand their …

Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence
mechanical properties and tissue quality. There is a growing appreciation for how water can …

Chronic kidney disease (CKD) is a common disease of aging and increases fracture risk
over advanced age alone. Aging and CKD differently impair bone turnover and …

Chronic kidney disease–mineral bone disorder (CKD‐MBD) is a systemic disorder that
affects blood measures of bone and mineral homeostasis, vascular calcification, and bone …

The current clinical assessment of fracture risk lacks information about the inherent quality of
a person's bone tissue. Working toward an imaging-based approach to quantify both a bone …

Raloxifene (RAL) reduces clinical fracture risk despite modest effects on bone mass and
density. This reduction in fracture risk may be due to improved material level-mechanical …

The incidence of diabetes mellitus and the associated complications are growing worldwide,
affecting the patients' quality of life and exerting a considerable burden on health systems …

Background Rodent studies of bone in chronic kidney disease have primarily relied on end-
point examinations of bone microarchitecture. This study used longitudinal in vivo …

Accounting for the impact of AGEs on the skeleton in CKD patients may improve our
estimation of overall bone quality, fracture risk, and treatments to improve both bone quantity …