Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …

Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

Abstract CD4+ T helper (Th) cells exist in a variety of epigenetic states that determine their
function, phenotype, and capacity for persistence. These polarization states include Th1 …

Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential therapeutic modality
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …

Methods A PubMed search was conducted using the search terms “graft versus host
disease,”“acute GVHD,”“chronic GVHD,”“pathophysiology,”“diagnosis,” and “treatment.” …

Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

Graft-vs. host disease (GVHD), both acute and chronic are among the chief non-relapse
complications of allogeneic transplantation which still cause substantial morbidity and …