Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

PJ Derry, ML Hegde, GR Jackson, R Kayed… - Progress in …, 2020 - Elsevier
The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …

Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster

KD Fasae, AO Abolaji - Current opinion in insect science, 2022 - Elsevier
Highlights•Drosophila is a useful model to study interactions of non-essential heavy
metals.•Cd, Pb, and Hg reduce the development of Drosophila.•Cd, Pb, and Hg induce …

TDP-43/FUS in motor neuron disease: Complexity and challenges

EN Guerrero, H Wang, J Mitra, PM Hegde… - Progress in …, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per
100,000 people worldwide, encompasses at least five distinct pathological subtypes …

Pervasive genomic damage in experimental intracerebral hemorrhage: therapeutic potential of a mechanistic-based carbon nanoparticle

P Dharmalingam, G Talakatta, J Mitra, H Wang… - ACS …, 2020 - ACS Publications
Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the
severity of the hemorrhage itself as well as multiple deleterious effects of blood and its …

Toxicity of copper and zinc alone and in combination in Caenorhabditis elegans model of Huntington's disease and protective effects of rutin

LM Cordeiro, MV Soares, AF da Silva, LV Dos Santos… - Neurotoxicology, 2023 - Elsevier
Abstract Copper (Cu) and Zinc (Zn) are required in small concentrations for metabolic
functions, but are also toxic. There is a great concern about soil pollution by heavy metals …

Environmental factors modulating protein conformations and their role in protein aggregation diseases

S Devi, M Chaturvedi, S Fatima, S Priya - Toxicology, 2022 - Elsevier
The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …

Early life metal dysregulation in amyotrophic lateral sclerosis

C Figueroa‐Romero, KA Mikhail… - Annals of clinical …, 2020 - Wiley Online Library
Objective Deficiencies and excess of essential elements and toxic metals are implicated in
amyotrophic lateral sclerosis (ALS), but the age when metal dysregulation appears remains …

A thorough understanding of the adsorption of Ni (II), Cd (II) and Zn (II) on goethite using experiments and molecular dynamics simulation

B Dash, B Dash, SS Rath - Separation and Purification Technology, 2020 - Elsevier
The study evaluates the efficiencies of the removal of three heavy metals, such as Ni (II), Cd
(II) and Zn (II), from water using goethite as the adsorbent. Batch adsorption experiments …

The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from eryptosis and ferroptosis

PJ Derry, ATT Vo, A Gnanansekaran, J Mitra… - Frontiers in Cellular …, 2020 - frontiersin.org
Intracerebral hemorrhage (ICH) is a particularly devastating event both because of the direct
injury from space-occupying blood to the sequelae of the brain exposed to free blood …

Association between heavy metal levels and acute ischemic stroke

CH Lin, YT Hsu, CC Yen, HH Chen, CJ Tseng… - Journal of Biomedical …, 2018 - Springer
Background Few studies have examined the relationship between the amounts of heavy
metal and stroke incidence. The aim of this study was to explore the relationship between …