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[HTML][HTML] In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review
Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …
step in the early stages of drug discovery. In particular, the absorption of orally administered …
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …
effectiveness, ease of administration, and high patient compliance. However, the absorption …
Pharmaceutical cocrystals: walking the talk
Pharmaceutical cocrystals belong to a sub-class of cocrystals wherein one of the
components is a drug molecule (or an active pharmaceutical ingredient, API) and the …
components is a drug molecule (or an active pharmaceutical ingredient, API) and the …
[HTML][HTML] Current evidence on the bioavailability of food bioactive peptides
L Amigo, B Hernández-Ledesma - Molecules, 2020 - mdpi.com
Food protein-derived bioactive peptides are recognized as valuable ingredients of functional
foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases …
foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases …
[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
[HTML][HTML] Intestinal permeability and drug absorption: predictive experimental, computational and in vivo approaches
The main objective of this review is to discuss recent advancements in the overall
investigation and in vivo prediction of drug absorption. The intestinal permeability of an …
investigation and in vivo prediction of drug absorption. The intestinal permeability of an …
The delivery of sensitive food bioactive ingredients: Absorption mechanisms, influencing factors, encapsulation techniques and evaluation models
Food-sourced bioactive compounds have drawn much attention due to their health benefits
such as anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing …
such as anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing …
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Monolayers of a well differentiated human intestinal epithelial cell line, Caco-2, were used
as a model to study passive drug absorption across the intestinal epithelium. Absorption rate …
as a model to study passive drug absorption across the intestinal epithelium. Absorption rate …
Development of a human primary gut-on-a-chip to model inflammatory processes
C Beaurivage, A Kanapeckaite, C Loomans… - Scientific reports, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex multi-factorial disease for which
physiologically relevant in vitro models are lacking. Existing models are often a compromise …
physiologically relevant in vitro models are lacking. Existing models are often a compromise …
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics
The human intestinal Caco-2 cell line has been extensively used over the last twenty years
as a model of the intestinal barrier. The parental cell line, originally obtained from a human …
as a model of the intestinal barrier. The parental cell line, originally obtained from a human …