The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

TET2 is recurrently mutated in acute myeloid leukemia (AML) and its deficiency promotes
leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem …

Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …

Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have
demonstrated stunning clinical efficacy in many cancer types. However, most patients do not …

The tumor microenvironment significantly influences therapeutic response and clinical
outcome. Microenvironment-mediated drug resistance can be induced by soluble factors …

Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence
indicates that targeting the tumor microenvironment could complement traditional treatment …

The tumor microenvironment (TME) not only plays a pivotal role during cancer progression
and metastasis but also has profound effects on therapeutic efficacy. In the case of …

Abstract B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell
death at the mitochondrion. It remains a challenge to identify those tumors that are best …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …