Ruminococcus gnavus: friend or foe for human health

EH Crost, E Coletto, A Bell… - FEMS Microbiology …, 2023 - academic.oup.com
Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy
individuals, and for several decades, its study has been limited to specific enzymes or …

Intestinal mucus and their glycans: A habitat for thriving microbiota

AS Luis, GC Hansson - Cell Host & Microbe, 2023 - cell.com
The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to
bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major …

Microbial tryptophan catabolites in health and disease

HM Roager, TR Licht - Nature communications, 2018 - nature.com
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

[HTML][HTML] Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care

A Gilliland, JJ Chan, TJ De Wolfe, H Yang, BA Vallance - Gastroenterology, 2024 - Elsevier
The gut microbiota plays a significant role in the pathogenesis of both forms of inflammatory
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide

MT Henke, DJ Kenny, CD Cassilly… - Proceedings of the …, 2019 - National Acad Sciences
A substantial and increasing number of human diseases are associated with changes in the
gut microbiota, and discovering the molecules and mechanisms underlying these …

Introduction to the human gut microbiota

E Thursby, N Juge - Biochemical journal, 2017 - portlandpress.com
The human gastrointestinal (GI) tract harbours a complex and dynamic population of
microorganisms, the gut microbiota, which exert a marked influence on the host during …

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

AB Hall, M Yassour, J Sauk, A Garner, X Jiang… - Genome medicine, 2017 - Springer
Background Inflammatory bowel disease (IBD) is characterized by chronic inflammation of
the gastrointestinal tract that is associated with changes in the gut microbiome. Here, we …

Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation

M Wlodarska, C Luo, R Kolde, E d'Hennezel… - Cell host & …, 2017 - cell.com
Host factors in the intestine help select for bacteria that promote health. Certain commensals
can utilize mucins as an energy source, thus promoting their colonization. However, health …

The microbiome in inflammatory bowel diseases: from pathogenesis to therapy

S Liu, W Zhao, P Lan, X Mou - Protein & cell, 2021 - academic.oup.com
Inflammatory bowel disease (IBD) has become a global disease with accelerating incidence
worldwide in the 21st century while its accurate etiology remains unclear. In the past …

Akkermansia muciniphila and its role in regulating host functions

M Derrien, C Belzer, WM de Vos - Microbial pathogenesis, 2017 - Elsevier
Akkermansia muciniphila is an intestinal bacterium that was isolated a decade ago from a
human fecal sample. Its specialization in mucin degradation makes it a key organism at the …