Reaction-diffusion model as a framework for understanding biological pattern formation

S Kondo, T Miura - science, 2010 - science.org
The Turing, or reaction-diffusion (RD), model is one of the best-known theoretical models
used to explain self-regulated pattern formation in the develo** animal embryo. Although …

Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases

HZ Ke, WG Richards, X Li, MS Ominsky - Endocrine reviews, 2012 - academic.oup.com
The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

Stem cell differentiation trajectories in Hydra resolved at single-cell resolution

S Siebert, JA Farrell, JF Cazet, Y Abeykoon… - Science, 2019 - science.org
INTRODUCTION The cnidarian polyp Hydra undergoes continual self-renewal and is
capable of whole-body regeneration from a small piece of tissue. The stem cell populations …

Distinct antimicrobial peptide expression determines host species-specific bacterial associations

S Franzenburg, J Walter, S Künzel, J Wang… - Proceedings of the …, 2013 - pnas.org
Animals are colonized by coevolved bacterial communities, which contribute to the host's
health. This commensal microbiota is often highly specific to its host-species, inferring strong …

The evolution of the Wnt pathway

TW Holstein - Cold Spring Harbor Perspectives in …, 2012 - cshperspectives.cshlp.org
Wnt genes are important regulators of embryogenesis and cell differentiation in vertebrates
and insects. New data revealed by comparative genomics have now shown that members of …

[HTML][HTML] Multiple Wnts are involved in Hydra organizer formation and regeneration

T Lengfeld, H Watanabe, O Simakov, D Lindgens… - Developmental …, 2009 - Elsevier
Wnt genes and β-Catenin signaling are involved in axial patterning processes in vertebrate
embryogenesis in setting up the Spemann–Mangold organizer in amphibian embryos. An …

Model systems for regeneration: Hydra

MC Vogg, B Galliot, CD Tsiairis - Development, 2019 - journals.biologists.com
The freshwater polyp Hydra provides a potent model system for investigating the conditions
that promote wound healing, reactivation of a developmental process and, ultimately …

[HTML][HTML] Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response

KA Gurley, SA Elliott, O Simakov, HA Schmidt… - Developmental …, 2010 - Elsevier
Regeneration is widespread throughout the animal kingdom, but our molecular
understanding of this process in adult animals remains poorly understood. Wnt/β-catenin …

Unifying principles of regeneration I: Epimorphosis versus morphallaxis

K Agata, Y Saito, E Nakajima - Development, growth & …, 2007 - Wiley Online Library
Because research on regeneration has a long history, some classic definitions and concepts
about regeneration which were established in earlier times have been retained without …

[HTML][HTML] Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration

TCG Bosch - Developmental biology, 2007 - Elsevier
The basis for Hydra's enormous regeneration capacity is the “stem cellness” of its epithelium
which continuously undergoes self-renewing mitotic divisions and also has the option to …